Длительная терапия ИБС: профилактика приступов стенокардии (монотерапия или в составе комбинированной терапии) лечение кохлео-вестибулярных нарушений ишемической природы (в т.ч. головокружение, шум в ушах, нарушения слуха) хориоретинальные сосудистые нарушения с ишемическим компонентом.
Противопоказания
Беременность, период лактации (грудное вскармливание), повышенная чувствительность к триметазидину.
1 таблетка содержит: Активное вещество: триметазидина дигидрохлорид 35 мг.
Фармакологические свойства
Средство, нормализующее энергетический метаболизм клеток, подвергшихся гипоксии или ишемии. Предотвращает снижение внутриклеточного содержания АТФ, обеспечивает нормальное функционирование мембранных ионных каналов, трансмембранный перенос ионов калия и натрия и сохранение клеточного гомеостаза. Триметазидин замедляет окисление жирных кислот за счет селективного ингибирования длинноцепочечной 3-кетоацетил-КоА тиолазы, что приводит к повышению окисления глюкозы и к восстановлению сопряжения между гликолизом и окислительным декарбоксилированием и, как было показано, обеспечивает защиту миокарда от ишемии. Переключение окисления жирных кислот на окисление глюкозы лежит в основе антиангинального действия триметазидина. В экспериментальных исследованиях на животных показано, что триметазидин поддерживает энергетический метаболизм сердца и нейросенсорных органов в периоды эпизодов ишемии, уменьшает величину внутриклеточного ацидоза и степень изменений в трансмембранном ионном потоке, возникающем при ишемии, понижает уровень миграции и инфильтрации полинуклеарных нейтрофилов в ишемических и реперфузионных тканях сердца, уменьшает размер повреждения миокарда, при этом не оказывает влияния на гемодинамику.
Показания к применению
Длительная терапия ИБС: профилактика приступов стенокардии (монотерапия или в составе комбинированной терапии) лечение кохлео-вестибулярных нарушений ишемической природы (в т.ч. головокружение, шум в ушах, нарушения слуха) хориоретинальные сосудистые нарушения с ишемическим компонентом.
Противопоказания
Беременность, период лактации (грудное вскармливание), повышенная чувствительность к триметазидину.
Способ применения и дозы
Принимают внутрь в дозе 40-60 мг/сут, кратность приема 2-3 раза/сут. Продолжительность терапии устанавливают индивидуально, в зависимости от клинической ситуации.
Для описания товара использована информация от партнера 36.6
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