В 100 г крема: фентиконазола нитрат 2 гВспомогательные вещества: вода - 60.5 г, глицерил моностеарат - 3 г, динатрия эдетат - 500 мг, эфир жирных кислот и макрогола - 15 г, ланолин гидрогенизированный - 1 г, масло миндаля - 10 г, пропиленгликоль - 5 г, цетиловый спирт - 3 г.
Фармакологические свойства
Противогрибковый препарат широкого спектра действия для местного применения. Фентиконазол является синтетическим производным имидазола (его рацемическая смесь в форме азотнокислой соли фентиконазола). Оказывает местное фунгицидное и фунгистатическое действие. Обладает также антибактериальным и противовоспалительным действием. Механизм действия заключается в ингибировании синтеза эргостерола, регулирующего проницаемость клеточной мембраны грибов. Активен в отношении дрожжевых грибов Candida spp. (включая Candida albicans) и грамположительных бактерий (Staphylococcus aureus, Streptococcus spp.), а также в отношении Trichomonas vaginalis. В отличие от других известных азольных соединений (в частности, эконазола, миконазола и кетоконазола) фентиконазол ингибирует биосинтез протеаз Candida spp. При концентрациях ниже МПК - от 0.25 до 16 мкг/мл. Это действие не зависит от величины антимикотической активности и обусловлено ингибированием одной из стадий образования протеолитических ферментов дрожжеподобными грибами.
I триместр беременности; повышенная чувствительность к препарату.
Применение при беременности и в период грудного вскармливания
В настоящее время данные об эффективности и безопасности применения Ломексина при беременности и в период лактации (грудного вскармливания) отсутствуют. Применение препарата в I триместре беременности противопоказано.
Способ применения и дозы
Крем вагинальный 2% вводят глубоко во влагалище (приблизительно 5 г) 1 раз/сут вечером, перед сном, при необходимости - 2 раза/сут, утром и вечером. Лечение проводят до полного клинического выздоровления, обычно 3-6 дней.
Побочное действие
Аллергические реакции: редко - крапивница, сыпь, эритема. Местные реакции: жжение, зуд, местное раздражение. Ломексин, как правило, хорошо переносится, побочные эффекты носят транзиторный характер и не требуют отмены препарата.
Передозировка
В настоящее время о случаях передозировки препарата Ломексин не сообщалось.
Особые указания
При продолжительном применении препарата возможно развитие сенсибилизации. В этом случае необходимо прекратить лечение, и пациентка должна обратиться к лечащему врачу. При отсутствии эффекта в течение 3 недель терапии лечение следует прекратить и уточнить диагноз. Во избежание реинфицирования рекомендуется одновременно проводить лечение партнера кремом, который наносят на головку полового члена и крайнюю плоть.
Для описания товара использована информация от партнера 36.6
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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