Лиофилизат для приготовления раствора для внутримышечного введения.
Состав
Иммуномакса 100 ЕД; 200 ЕД.
Натрия хлорида 8,1 мг; 7,2 мг.
Описание
Лиофилизированный порошок белого цвета.
Фармакотерапевтическая группа
Иммуномодулирующее средство.
Фармакологические свойства
Иммуномакс усиливает иммунную защиту от вирусных и
бактериальных инфекций.
Иммунофармакологические механизмы действия препарата состоят
в том, что
Иммуномакс активирует следующие звенья иммунной системы:
• NK-клетки, которые через 2-3 часа после воздействия
Иммуномакса усиленно экспрессируют молекулы активации CD69. Цитолитическая
активность NK-клеток возрастает в 3 раза;
• циркулирующие моноциты через 2-4 часа после активации
Иммуномаксом начинают секретировать цитокины: интерлейкин-8,
интерлейкин-1 и фактор некроза опухолей альфа;
• нейтрофильные гранулоциты активируются при посредстве
моноцитов, прямого действия на нейтрофильные гранулоциты препарат не
оказывает.
Секретируемый моноцитами интерлейкин-8 вызывает активацию
нейтрофильных гранулоцитов, которая отчетливо проявляется через 24 часа
после воздействия Иммуномаксом;
• тканевые макрофаги, что проявляется в изменении морфологии
этих клеток, усилении продукции бактерицидных субстанций, изменении
активности 5’- нуклеотидазы;
• образование антител против чужеродных антигенов,
растворимых и корпускулярных;
Иммуномакс усиливает защиту от инфекций, вызванных вирусами
(вирус папилломы человека, вирус простого герпеса, парвовирус, вирус чумы
плотоядных и др.) или бактериями (кишечная палочка, сальмонелла, стафилококк,
хламидия, микоплазма, уреаплазма и др.). Это действие препарата проявляется у
взрослых и новорожденных при введении Иммуномакса различными путями: внутримышечно,
внутривенно, внутрибрюшинно, per os.
Фармакокинетика препарата не изучалась в связи с его
пептидогликановой природой и очень малыми действующими дозами.
Показания к применению
• коррекция ослабленного иммунитета;
• лечение патологических состояний (кондиломы, бородавки, дисплазии и др.), вызванных вирусом папилломы человека;
• лечение инфекций, вызванных вирусом простого герпеса, хламидией, микоплазмой, уреаплазмой, другими бактериями и вирусами.
Противопоказания
Индивидуальная гиперчувствительность к Иммуномаксу. Детский возраст до 12 лет.
Применение при беременности и в период грудного вскармливания
Применение возможно только, если потенциальная польза для беременной превышает возможный вред для плода. Иммуномакс не рекомендуется для приема кормящими матерями. Особенностей применения лекарственного препарата детьми и взрослыми, имеющими хронические заболевания, нет.
Способ применения и дозы
Перед употреблением препарат растворяют в 1 мл воды для инъекций.
Рекомендуемая доза для взрослых и детей 12 лет и старше составляет 100-200 ЕД в
зависимости от тяжести заболевания. Препарат вводят внутримышечно, один раз в день.
Курс лечения – 6 инъекций в 1, 2, 3, 8, 9, 10 дни лечения.
Для лечения рецидивирующих аногенитальных бородавок курс из 6 инъекций по 200 ЕД Иммуномакса сочетают с деструкцией бородавок одним из общепринятых методов: криодеструкция, электрокоагуляция, лазерная деструкция или солкодерм.
Для лечения инфекций, вызванных бактериями или вирусами, проводят курс из 6 инъекций по 100-200 ЕД Иммуномакса.
Для коррекции ослабленного иммунитета проводят курс из 3-6 инъекций по 100-200 ЕД Иммуномакса.
Побочное действие
Не обнаружено.
Передозировка
Симптомы передозировки не описаны.
Взаимодействие с другими лекарственными средствами
Не описано.
Влияние на способность управлять автомобилем и движущимися механизмами
Препарат не влияет на способность управлять транспортными средствами, движущимися механизмами и заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Лиофилизат для приготовления раствора для внутримышечного введения.
По 100 ЕД или 200 ЕД во флакон или ампулу.
- 3 флакона или ампулы вместе с инструкцией по применению в картонную пачку;
- 1 флакон или ампулу с препаратом, 1 ампулу с водой для инъекций 2 мл, 1 шприц одноразовый стерильный 2 мл, 1 салфетку прединъекционную вместе с инструкцией по применению в пачку (Комплект);
- 3 флакона или ампулы с препаратом, 3 ампулы с водой для инъекций 2 мл, 3 шприца одноразовых стерильных 2 мл, 3 салфетки прединъекционные вместе с инструкцией по применению в пачку (Комплект);
- 30 флаконов или ампул с препаратом с 5 инструкциями по применению - в (Для стационаров).
Условия хранения
Хранить при температуре от 4° С до 8° С. Хранить в недоступном для детей месте.
Срок годности
2 года. Не использовать по истечении срока годности.
Условия отпуска
Отпускается по рецепту.
Организация, принимающая претензии потребителей
ОАО «Авексима», 125284, Россия, г. Москва, Ленинградский проспект, д. 31А, стр. 1.
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Цитолитическая\nактивность NK-клеток возрастает в 3 раза;"}},{"type":"paragraph","data":{"text":"• циркулирующие моноциты через 2-4 часа после активации\nИммуномаксом начинают секретировать цитокины: интерлейкин-8,\nинтерлейкин-1 и фактор некроза опухолей альфа;"}},{"type":"paragraph","data":{"text":"• нейтрофильные гранулоциты активируются при посредстве\nмоноцитов, прямого действия на нейтрофильные гранулоциты препарат не\nоказывает."}},{"type":"paragraph","data":{"text":"Секретируемый моноцитами интерлейкин-8 вызывает активацию\nнейтрофильных гранулоцитов, которая отчетливо проявляется через 24 часа\nпосле воздействия Иммуномаксом;"}},{"type":"paragraph","data":{"text":"• тканевые макрофаги, что проявляется в изменении морфологии\nэтих клеток, усилении продукции бактерицидных субстанций, изменении\nактивности 5’- нуклеотидазы;"}},{"type":"paragraph","data":{"text":"• образование антител против чужеродных антигенов,\nрастворимых и корпускулярных;"}},{"type":"paragraph","data":{"text":"Иммуномакс усиливает защиту от инфекций, вызванных вирусами\n(вирус папилломы человека, вирус простого герпеса, парвовирус, вирус чумы\nплотоядных и др.) или бактериями (кишечная палочка, сальмонелла, стафилококк,\nхламидия, микоплазма, уреаплазма и др.). Это действие препарата проявляется у\nвзрослых и новорожденных при введении Иммуномакса различными путями: внутримышечно,\nвнутривенно, внутрибрюшинно, per os."}},{"type":"paragraph","data":{"text":"Фармакокинетика препарата не изучалась в связи с его\nпептидогликановой природой и очень малыми действующими дозами."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"• коррекция ослабленного иммунитета;"}},{"type":"paragraph","data":{"text":"• лечение патологических состояний (кондиломы, бородавки, дисплазии и др.), вызванных вирусом папилломы человека;"}},{"type":"paragraph","data":{"text":"• лечение инфекций, вызванных вирусом простого герпеса, хламидией, микоплазмой, уреаплазмой, другими бактериями и вирусами."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Индивидуальная гиперчувствительность к Иммуномаксу. 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Препарат вводят внутримышечно, один раз в день."}},{"type":"paragraph","data":{"text":"Курс лечения – 6 инъекций в 1, 2, 3, 8, 9, 10 дни лечения."}},{"type":"paragraph","data":{"text":"Для лечения рецидивирующих аногенитальных бородавок курс из 6 инъекций по 200 ЕД Иммуномакса сочетают с деструкцией бородавок одним из общепринятых методов: криодеструкция, электрокоагуляция, лазерная деструкция или солкодерм."}},{"type":"paragraph","data":{"text":"Для лечения инфекций, вызванных бактериями или вирусами, проводят курс из 6 инъекций по 100-200 ЕД Иммуномакса."}},{"type":"paragraph","data":{"text":"Для коррекции ослабленного иммунитета проводят курс из 3-6 инъекций по 100-200 ЕД Иммуномакса."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Не обнаружено."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы передозировки не описаны."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Не описано."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не влияет на способность управлять транспортными средствами, движущимися механизмами и заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Лиофилизат для приготовления раствора для внутримышечного введения."}},{"type":"paragraph","data":{"text":"По 100 ЕД или 200 ЕД во флакон или ампулу."}},{"type":"paragraph","data":{"text":"- 3 флакона или ампулы вместе с инструкцией по применению в картонную пачку;"}},{"type":"paragraph","data":{"text":"- 1 флакон или ампулу с препаратом, 1 ампулу с водой для инъекций 2 мл, 1 шприц одноразовый стерильный 2 мл, 1 салфетку прединъекционную вместе с инструкцией по применению в пачку (Комплект);"}},{"type":"paragraph","data":{"text":"- 3 флакона или ампулы с препаратом, 3 ампулы с водой для инъекций 2 мл, 3 шприца одноразовых стерильных 2 мл, 3 салфетки прединъекционные вместе с инструкцией по применению в пачку (Комплект);"}},{"type":"paragraph","data":{"text":"- 30 флаконов или ампул с препаратом с 5 инструкциями по применению - в (Для стационаров)."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре от 4° С до 8° С. 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