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Перед всасыванием тиамина гидрохлорид\nвысвобождается из связанного состояния пищеварительными ферментами. В крови\nконцентрация тиамина гидрохлорида сравнительно низкая."}},{"type":"paragraph","data":{"text":"В плазме обнаруживается\nпреимущественно свободный тиамин, в эритроцитах и лейкоцитах – его фосфорные\nэфиры. Половина общего количества содержится в поперечно полосатых мышцах\n(включая миокард) и около 40% – во внутренних органах."}},{"type":"paragraph","data":{"text":"Фосфорилирование\nпроисходит в печени. Наиболее активным фосфорным эфиром является\nтиаминдифосфат, обладающий коферментной активностью. Накапливается в основном в\nпечени, сердце, мозге, почках, селезенке. Выводится через кишечник и почками."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Умеренно или слабо выраженный болевой синдром, различного\nгенеза: головная боль (в том числе мигрень), зубная боль, невралгия, боли в\nмышцах (миалгия), боли в суставах (артралгия), корешковый синдром, менструальные боли (альгодисменорея)."}},{"type":"paragraph","data":{"text":"Лихорадочный синдром\nпри \"простудных\" и других инфекционно-воспалительных заболеваниях\n(при установленном диагнозе)."}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность к компонентам\nпрепарата;"}},{"type":"paragraph","data":{"text":"Повышенная чувствительность к другим производным пиразолона – фенилбутазону;\n"}},{"type":"paragraph","data":{"text":"Тяжелая печеночная и/или почечная недостаточность;"}},{"type":"paragraph","data":{"text":"Бронхоспазм;"}},{"type":"paragraph","data":{"text":"Дефицит глюкозо-6-фосфатдегидрогеназы (синдром врожденной недостаточности\nфермента глюкозо-6-фосфатдегидрогеназы);"}},{"type":"paragraph","data":{"text":"Заболевания системы крови;"}},{"type":"paragraph","data":{"text":"Бессонница;"}},{"type":"paragraph","data":{"text":"Неконтролируемая артериальная гипертензия;"}},{"type":"paragraph","data":{"text":"Выраженный атеросклероз;"}},{"type":"paragraph","data":{"text":"Повышение внутриглазного давления;"}},{"type":"paragraph","data":{"text":"Беременность и период грудного\nвскармливания;"}},{"type":"paragraph","data":{"text":"Детский возраст (до 12 лет)."}}]},{"id":9,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"нарушения функции печени и/или почек."}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь после еды по 1 таблетке 2-3 раза в\nпервой половине дня. Максимальная\nразовая доза \u003ci\u003eдля взрослых\u003c/i\u003e\u003ci\u003e и подростков с 16 лет -\u003c/i\u003e\u003ci\u003e \u003c/i\u003e2 таблетки, максимальная суточная доза – 6\nтаблеток не более 1-2 дней."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДетям в возрасте от 12 до 16\nлет\u003c/i\u003e - по половине или\nодной таблетке 2-3 раза в день, максимальная суточная доза – 4 таблетки."}},{"type":"paragraph","data":{"text":"Продолжительность приема – не более 5 дней при\nназначении в качестве обезболивающего средства и 3-х дней в качестве\nжаропонижающего средства."}},{"type":"paragraph","data":{"text":"Если симптомы заболевания продолжаются или усугубляются,\nследует обратиться к врачу."}},{"type":"paragraph","data":{"text":"Увеличение суточной дозы препарата или\nпродолжительности лечения возможно только под наблюдением врача."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны\nжелудочно-кишечного тракта: \u003c/i\u003eпотеря аппетита, тошнота, рвота, холестаз, желтуха;"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органов\nкроветворения:\u003c/i\u003e тромбоцитопения, лейкопения, агранулоцитоз, гемолитическая анемия,\nпурпура;"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны центральной\nнервной системы:\u003c/i\u003e бессонница, головокружение, повышенная возбудимость;"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e ощущение сердцебиения, нарушения ритма сердца;"}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции:\u003c/i\u003e кожная сыпь, зуд, покраснение, отек Квинке, анафилактический шок; бронхоспазм."}},{"type":"paragraph","data":{"text":"О всех побочных\nэффектах следует сообщать лечащему врачу."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e тошнота и рвота иногда с кровью,\nболи в области желудка, психическое и двигательное\nвозбуждение, тахикардия, нарушения ритма сердца, возможно уменьшение или увеличение диуреза, судороги, тревожность,\nспутанность сознания, делирий, обезвоживание, гипертермия, головная боль,\nповышенная тактильная или болевая чувствительность, тремор или мышечные\nподергивания; звон в ушах, эпилептические припадки (при острой передозировке –\nтонико-клонические)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e следует\nнемедленно обратиться за медицинской помощью. Пострадавшему следует сделать\nпромывание желудка, назначить адсорбенты (например, активированный уголь),\nслабительные лекарственные средства. При необходимости проводят\nсимптоматическое лечение (при геморрагическом\nгастрите – введение антацидных лекарственных средств и\nпромывание желудка ледяным 0,9 % раствором натрия хлорида; поддержание\nвентиляции легких и оксигенации; при эпилептических припадках – внутривенно диазепам, фенобарбитал или фенитоин; поддержание баланса\nжидкости и солей)."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Одновременное\nприменение метамизола натрия (анальгина) с другими ненаркотическими\nанальгетиками, нестероидными противовоспалительными препаратами может привести\nк взаимному усилению токсических эффектов."}},{"type":"paragraph","data":{"text":"Трициклические\nантидепрессанты, пероральные контрацептивные средства, аллопуринол нарушают\nметаболизм метамизола натрия в печени и повышают его токсичность."}},{"type":"paragraph","data":{"text":"Барбитураты,\nфенилбутазон (бутадион) и другие индукторы микросомальных ферментов печени\nослабляют действие метамизола натрия. Одновременное применение метамизола\nнатрия с циклоспорином снижает концентрацию последнего в крови."}},{"type":"paragraph","data":{"text":"Седативные\nсредства и транквилизаторы усиливают обезболивающее действие метамизола натрия."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Чрезмерное\nупотребление кофеинсодержащих продуктов (чай, кофе) на фоне лечения может\nвызвать симптомы передозировки."}},{"type":"paragraph","data":{"text":"С осторожностью и\nпод врачебным контролем применяют у пациентов с нарушением функции печени или\nпочек."}},{"type":"paragraph","data":{"text":"Одновременное\nприменение препарата с алкогольсодержащими напитками не рекомендуется."}},{"type":"paragraph","data":{"text":"У пациентов с\nатопической бронхиальной астмой, поллинозами, имеется повышенный риск развития\nреакций гиперчувствительности."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Необходимо соблюдать осторожность при управлении\nтранспортными средствами и работе с механизмами, требующими повышенной\nконцентрации внимания и быстроты психомоторных реакций, поскольку при приеме\nпрепарата возможно развитие головокружения."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки. 10 таблеток в блистер из\nтрехслойной ПВХ/ПВДХ/ПВХ пленки или двухслойной ПВХ/ПВДХ пленки и алюминиевой\nфольги."}},{"type":"paragraph","data":{"text":"1 или 2 блистера вместе с\nинструкцией по применению в пачке картонной с контролем первого вскрытия."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при\nтемпературе не выше 25 ºС."}},{"type":"paragraph","data":{"text":"Хранить в\nнедоступном для детей месте!"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Не применять по\nистечении срока годности."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Балканфарма-Дупница АД, Болгария, 2600 Дупница, ул.\nСамоковское шоссе, д. 3"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО\n«Тева»"}},{"type":"paragraph","data":{"text":"115054,\nМосква, ул. Валовая, 35,"}},{"type":"paragraph","data":{"text":"тел.: +7 (495) 644 22 34,"}},{"type":"paragraph","data":{"text":"факс: +7 (495) 644 22 35"}},{"type":"paragraph","data":{"text":"адрес в интернете: \u003ca href=\"http://www.teva.ru\"\u003ewww.teva.ru\u003c/a\u003e"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ФармакодинамикаМетамизолнатрияявляется производным пиразолона и обладает анальгезирующим, жаропонижающим и слабым противовоспалительным действием, механизм которого связан с угнетением синтеза простагландинов за счет ингибирования циклооксигеназы.Кофеин– оказывает стимулирующее действие на центральную нервную систему (ЦНС), главным образом на кору головного мозга, дыхательный и сосудодвигательный центры. Повышает умственную и физическую работоспособность, уменьшает сонливость, чувство усталости. Кофеин увеличивает проницаемость гистогематических барьеров и повышает биодоступность ненаркотических анальгетиков, способствуя тем самым усилению терапевтического эффекта.Тиамин(витамин В1) участвует в обмене веществ, и способствует улучшению нервно-рефлекторной проводимости.ФармакокинетикаФармакокинетические свойства препарата Седальгин®Плюс зависят от фармакокинетики компонентов, входящих в его состав.Метамизол натрияМетамизол натрия всасывается быстро и полностью в желудочно-кишечном тракте, достигая максимальной концентрации в плазме в среднем через 60-90 минут после приема. Связывается с белками плазмы и подвергается метаболизму в печени. По пути неферментного гидролиза расщепляется до 4-метиламиноантипирина с дальнейшим метаболизмом через активный 4–аминоантипирин до 4-ацетиламиноантипирина – основного метаболита, 90% которого выводится через почки и 10% – с желчью с периодом полувыведения около 10 часов.КофеинКофеин, входящий в состав препарата, почти полностью всасывается, максимальная концентрация в плазме крови определяется через 30-40 мин. Быстро проходит через гематоэнцефалический и плацентарный барьеры, поступает в грудное молоко, выводится (в т.ч. в виде метаболитов) в основном почками.ТиаминАбсорбция – высокая, на всем протяжении тонкой кишки. Перед всасыванием тиамина гидрохлорид высвобождается из связанного состояния пищеварительными ферментами. В крови концентрация тиамина гидрохлорида сравнительно низкая. В плазме обнаруживается преимущественно свободный тиамин, в эритроцитах и лейкоцитах – его фосфорные эфиры. Половина общего количества содержится в поперечно полосатых мышцах (включая миокард) и около 40% – во внутренних органах. Фосфорилирование происходит в печени. Наиболее активным фосфорным эфиром является тиаминдифосфат, обладающий коферментной активностью. Накапливается в основном в печени, сердце, мозге, почках, селезенке. 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