Гроприносин-Рихтер Сироп, флакон, 150 мл, 50 мг / мл

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Представляет собой комплекс,\nсодержащий инозин и соль пара-ацетамидобензойной кислоты с N,N-диметиламино-2-пропанолом\nв молярном соотношении 1:3."}},{"type":"paragraph","data":{"text":"Эффективность\nкомплекса определяется присутствием инозина, второй компонент повышает его\nдоступность для лимфоцитов. Инозин пранобекс блокирует размножение вирусных\nчастиц путем повреждения генетического аппарата, стимулирует активность\nмакрофагов, пролиферацию лимфоцитов и образование цитокинов. Второй компонент\nповышает доступность препарата Гроприносин-Рихтер для лимфоцитов. Уменьшает\nклинические проявления вирусных заболеваний, ускоряет реконвалесценцию,\nповышает резистентность организма."}},{"type":"paragraph","data":{"text":"При назначении\nинозина пранобекса в качестве вспомогательного лекарственного средства при\nинфекционном поражении слизистых оболочек и кожи, вызванных вирусом Herpes\nsimplex, происходит более быстрое заживление пораженной поверхности, чем при\nлечении традиционным способом. Реже возникают новые пузырьки, отеки, эрозии и\nрецидивы болезни. При своевременном применении препарата сокращается частота\nвозникновения вирусных инфекций, снижается длительность и тяжесть заболевания."}},{"type":"header","data":{"text":"Фармакокинетика","level":4}},{"type":"paragraph","data":{"text":"После приема\nвнутрь препарат хорошо всасывается из желудочно-кишечного тракта (ЖКТ) и\nобладает хорошей биодоступностью. Максимальная концентрация ингредиентов в\nплазме крови определяется через 1?2 ч. Быстро подвергается метаболизму и\nвыделяется через почки. Метаболизируется аналогично эндогенным пуриновым\nнуклеотидам с образованием мочевой кислоты. N,N-диметиламино-2-пропанол\nметаболизируется до N-оксида, а 4-ацетамидобензоат - до о-ацилглюкуронида. Не\nобнаружено кумуляции препарата в организме. Период полувыведения (Т1/2) составляет\n3,5 ч для N,N-диметиламино-2-пропанола и 50 мин - для 4-ацетамидобензоата.\nПрепарат и его метаболиты из организма выводятся почками в течение 24?48 ч."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Лечение гриппа и других острых респираторных\nвирусных инфекций (ОРВИ) в составе комплексной терапии."}},{"type":"paragraph","data":{"text":"- Лечение лабиального герпеса (Herpes simplex) в\nсоставе комплексной терапии"}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к инозину пранобексу и\nдругим компонентам препарата."}},{"type":"paragraph","data":{"text":"- Подагра."}},{"type":"paragraph","data":{"text":"- Мочекаменная болезнь."}},{"type":"paragraph","data":{"text":"- Аритмии."}},{"type":"paragraph","data":{"text":"- Хроническая почечная недостаточность."}},{"type":"paragraph","data":{"text":"- Детский возраст до 3 лет (масса тела до 15-20 кг)."}},{"type":"paragraph","data":{"text":"- Беременность и период грудного вскармливания."}},{"type":"paragraph","data":{"text":"- Дефицит сахаразы/изомальтазы, непереносимость\nфруктозы, глюкозо-галактозная мальабсорбция."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Следует соблюдать осторожность при одновременном\nназначении с ингибиторами ксантиноксидазы, диуретиками, зидовудином, при острой\nпочечной или печеночной недостаточности, при сахарном диабете и длительном\nприменении Гроприносин-Рихтер."}},{"type":"paragraph","data":{"text":"Если вы принимаете какой-либо из перечисленных\nлекарственных препаратов или страдаете от указанных выше состояний, перед\nприменением препарата Гроприносин-Рихтер вам следует проконсультироваться с\nврачом."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата Гроприносин-Рихтер во время беременности и в период грудного вскармливания противопоказано, так как безопасность применения не установлена."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Способ применения"}},{"type":"paragraph","data":{"text":"Внутрь после еды. Для правильного дозирования прилагается мерный шприц для приёма препарата внутрь."}},{"type":"paragraph","data":{"text":"Дозы"}},{"type":"paragraph","data":{"text":"Доза препарата зависит от массы тела пациента и заболевания. Суточную дозу разделяют на несколько частей (3-4) которые следует принимать через равные промежутки времени в течение дня. Продолжительность лечения обычно составляет 5-14 дней. Приём препарата следует продолжить в течение 1-2 дней после исчезновения симптомов."}},{"type":"paragraph","data":{"text":"Рекомендуемая суточная доза для взрослых и пожилых пациентов а также детей 3 лет и старше (масса тела больше 15-20 кг) составляет 50 мг/кг массы тела в 3-4 приёма. 1 мл препарата Гроприносин-Рихтер содержит 50 мг инозина пранобекса."}},{"type":"paragraph","data":{"text":"Для лечения тяжёлых инфекций дозу можно индивидуально увеличивать до 100 мг/кг массы тела 4-6 раз в сутки. Максимальная суточная доза для взрослых составляет 3-4 г/сут (60-80 мл/сут)."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза для детей от 3 лет и старше - 50 мг/кг/сут."}},{"type":"paragraph","data":{"text":"Продолжительность лечения"}},{"type":"paragraph","data":{"text":"Острые инфекции: продолжительность лечения у взрослых и детей обычно от 5 до 14 дней. Лечение следует продолжать до момента исчезновения клинических симптомов и в течение ещё 1-2 дней после исчезновения симптомов. При необходимости длительность лечения может быть увеличена индивидуально под контролем врача."}},{"type":"paragraph","data":{"text":"Хронические рецидивирующие инфекции: у взрослых и детей лечение необходимо продолжать несколькими курсами по 5-10 дней с интервалом 8 дней. При проведении поддерживающей терапии доза может быть снижена до 500-1000 мг в сутки (10-20 мл/сут) в течение 30 дней."}},{"type":"paragraph","data":{"text":"Герпетические инфекции: лечение продолжается в течение 5-10 дней до исчезновения симптомов заболевания. Для уменьшения числа рецидивов в бессимптомный период препарат назначают по 500 мг 2 раза в сутки (20 мл/сут) в течение 30 дней."}},{"type":"paragraph","data":{"text":"Папилломавирусные инфекции: в качестве монотерапии препарат назначается на протяжении 14-28 дней взрослым в дозе 1000 мг 3 раза в сутки (60 мл/сут) детям - 250 мг на 5 кг массы тела (1 мл/кг/сут) 3-4 раза в сутки."}},{"type":"paragraph","data":{"text":"Рецидивирующие остроконечные кондиломы: в качестве монотерапии или в комбинации с хирургическим лечением препарат назначается взрослым в дозе 1000 мг 3 раза в сутки (60 мл/сут) детям - в дозе 250 мг на 5 кг массы тела (1 мл/кг/сут) в 3-4 приёма. Проводят 3 курса по 14-28 дней с интервалом 1 месяц."}},{"type":"paragraph","data":{"text":"Дисплазия шейки матки ассоциированная с папилломавирусом человека: 2-3 курса по 1000 мг 3 раза в сутки (60 мл/сут) в течение 10 дней с интервалом 10-14 дней."}},{"type":"paragraph","data":{"text":"Особые группы пациентов"}},{"type":"paragraph","data":{"text":"Применение у пожилых пациентов: необходимости в коррекции дозы нет препарат применяется так же как у пациентов среднего возраста. Следует учитывать что у пожилых пациентов чаще происходит повышение концентрации мочевой кислоты в сыворотке крови и в моче чем у пациентов среднего возраста."}},{"type":"paragraph","data":{"text":"Пациенты с почечной и печеночной недостаточностью: на фоне лечения препаратом Гроприносин-Рихтер следует каждые 2 недели проводить контроль содержания мочевой кислоты в сыворотке крови и моче. Контроль активности печеночных ферментов рекомендуется проводить каждые 4 недели при длительных курсах лечения препаратом."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Частота развития побочных действий после применения препарата классифицирована согласно рекомендациям ВОЗ: частые - >1% и <10%; нечастые - >01% и <1%."}},{"type":"paragraph","data":{"text":"Нарушения со стороны нервной системы"}},{"type":"paragraph","data":{"text":"Часто: головная боль, головокружение, утомляемость,\nплохое самочувствие, слабость. Нечасто: нервозность, сонливость, бессонница."}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного тракта"}},{"type":"paragraph","data":{"text":"Часто: снижение аппетита, тошнота, рвота, боль в\nэпигастрии."}},{"type":"paragraph","data":{"text":"Нечасто: диарея, запор."}},{"type":"paragraph","data":{"text":"Нарушения со стороны печени и желчевыводящих путей"}},{"type":"paragraph","data":{"text":"Часто: повышение активности трансаминаз и щелочной\nфосфатазы в плазме крови."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных тканей"}},{"type":"paragraph","data":{"text":"Часто: зуд, сыпь."}},{"type":"paragraph","data":{"text":"Нарушения со стороны почек и мочевыводящих путей"}},{"type":"paragraph","data":{"text":"Нечасто: полиурия."}},{"type":"paragraph","data":{"text":"Аллергические реакции"}},{"type":"paragraph","data":{"text":"Нечасто: пятнисто-папулезная сыпь, крапивница,\nангионевротический отек."}},{"type":"paragraph","data":{"text":"Общие расстройства и нарушения в месте введения"}},{"type":"paragraph","data":{"text":"Часто: боль в суставах, обострение подагры."}},{"type":"paragraph","data":{"text":"Лабораторные и инструментальные данные"}},{"type":"paragraph","data":{"text":"Часто: повышение концентрации азота мочевины крови.\nЕсли у Вас отмечаются побочные эффекты, указанные в инструкции или они\nусугубляются, или Вы заметили любые другие побочные эффекты, не указанные в\nинструкции, сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При передозировке показано промывание желудка и\nсимптоматическая терапия."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Иммунодепрессанты ослабляют иммуностимулирующий эффект инозина пранобекса."}},{"type":"paragraph","data":{"text":"Инозин пранобекс следует применять с осторожностью пациентам принимающим одновременно ингибиторы ксантиноксидазы (аллопуринол) или препараты способные блокировать канальцевую секрецию мочевой кислоты например \"петлевые\" диуретики (фуросемид торасемид этакриновая кислота) так как это может приводить к повышению концентрации мочевой кислоты в сыворотке крови."}},{"type":"paragraph","data":{"text":"Совместное применение инозина пранобекса с зидовудином приводит к увеличению концентрации зидовудина в плазме крови и удлиняет его период полувыведения. Таким образом при совместном применении инозина пранобекса с зидовудином может потребоваться коррекция дозы зидовудина."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Инозин пранобекс,\nкак и другие противовирусные средства, наиболее эффективен при острых вирусных\nинфекциях, если лечение начато на ранней стадии болезни (первые сутки)."}},{"type":"paragraph","data":{"text":"Поскольку инозин\nвыводится из организма в форме мочевой кислоты, при назначении препарата\nГроприносин-Рихтер одновременно с препаратами, увеличивающими концентрацию\nмочевой кислоты, или с препаратами, нарушающими функцию почек, необходимо\nконтролировать концентрацию мочевой кислоты в сыворотке крови."}},{"type":"paragraph","data":{"text":"У пожилых\nпациентов чаще, чем у пациентов среднего возраста, происходит повышение\nконцентрации мочевой кислоты в сыворотке крови и в моче."}},{"type":"paragraph","data":{"text":"Пациенты со\nзначительно повышенной концентрацией мочевой кислоты в организме могут\nодновременно принимать препараты, понижающие ее концентрацию."}},{"type":"paragraph","data":{"text":"Инозин пранобекс\nследует с осторожностью применять пациентам с острой печеночной\nнедостаточностью, поскольку препарат подвергается метаболизму в печени."}},{"type":"paragraph","data":{"text":"Гроприносин-Рихтер\nсодержит 650 мг сахарозы в 1 мл сиропа, что необходимо учитывать пациентам с\nсахарным диабетом. Препарат содержит метилпарагидроксибензоат и\nпропилпарагидроксибензоат, которые могут вызывать аллергические реакции\n(возможно, отсроченные). При появлении любых признаков аллергии, следует\nпрекратить прием препарата Гроприносин-Рихтер и обратиться к врачу."}},{"type":"paragraph","data":{"text":"Сохраняйте\nинструкцию. Она может понадобиться вновь. Если у Вас возникли вопросы,\nобратитесь к врачу."}},{"type":"paragraph","data":{"text":"Влияние на\nспособность к управлению транспортными средствами, механизмами"}},{"type":"paragraph","data":{"text":"Влияние инозина\nпранобекса на психомоторные функции организма и способность управлять\nтранспортными средствами и движущимися механизмами не исследовалось. При\nприменении препарата следует учитывать возможность возникновения головокружения\nи сонливости."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Сироп, 50 мг/мл - 150 мл флакон вместе с пластиковым шприцем и инструкцией по применению в уп"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"Срок годности после вскрытия флакона\n- 6 месяцев"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://apteka.ru/vendor/%D0%93%D0%B5%D0%B4%D0%B5%D0%BE%D0%BD%20%D0%A0%D0%B8%D1%85%D1%82%D0%B5%D1%80%20%D0%A0%D1%83%D0%BC%D1%8B%D0%BD%D0%B8%D1%8F%20%D0%90.%D0%9E.%2F%D0%93%D0%B5%D0%B4%D0%B5%D0%BE%D0%BD%20%D0%A0%D0%B8%D1%85%D1%82%D0%B5%D1%80%20%D0%9F%D0%BE%D0%BB%D1%8C%D1%88%D0%B0,%D0%9E%D0%9E/\"\u003eГедеон Рихтер Румыния А.О./Гедеон Рихтер Польша,ОО\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"Иммуностимулирующее средство, обладающее противовирусным действием. Представляет собой комплекс, содержащий инозин и соль пара-ацетамидобензойной кислоты с N,N-диметиламино-2-пропанолом в молярном соотношении 1:3. Эффективность комплекса определяется присутствием инозина, второй компонент повышает его доступность для лимфоцитов. Инозин пранобекс блокирует размножение вирусных частиц путем повреждения генетического аппарата, стимулирует активность макрофагов, пролиферацию лимфоцитов и образование цитокинов. Второй компонент повышает доступность препарата Гроприносин-Рихтер для лимфоцитов. Уменьшает клинические проявления вирусных заболеваний, ускоряет реконвалесценцию, повышает резистентность организма. При назначении инозина пранобекса в качестве вспомогательного лекарственного средства при инфекционном поражении слизистых оболочек и кожи, вызванных вирусом Herpes simplex, происходит более быстрое заживление пораженной поверхности, чем при лечении традиционным способом. Реже возникают новые пузырьки, отеки, эрозии и рецидивы болезни. При своевременном применении препарата сокращается частота возникновения вирусных инфекций, снижается длительность и тяжесть заболевания. После приема внутрь препарат хорошо всасывается из желудочно-кишечного тракта (ЖКТ) и обладает хорошей биодоступностью. Максимальная концентрация ингредиентов в плазме крови определяется через 1?2 ч. Быстро подвергается метаболизму и выделяется через почки. Метаболизируется аналогично эндогенным пуриновым нуклеотидам с образованием мочевой кислоты. N,N-диметиламино-2-пропанол метаболизируется до N-оксида, а 4-ацетамидобензоат - до о-ацилглюкуронида. Не обнаружено кумуляции препарата в организме. Период полувыведения (Т1/2) составляет 3,5 ч для N,N-диметиламино-2-пропанола и 50 мин - для 4-ацетамидобензоата. Препарат и его метаболиты из организма выводятся почками в течение 24?48 ч.","substance":[{"id":939,"title":"Инозин пранобекс","title_latin":"Inosinum pranobexum","slug":"inozin_pranobeks_939"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Гроприносин-Рихтер - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/87760/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/87760/share_default/"}},"diseases":[],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Аналоги","type":"analogs","products":[{"id":105579,"title":"Нормомед","subtitle":{"full":"Сироп, 120 мл, 50 мг/мл, для приема внутрь","short":"Сироп, 120 мл, 50 мг/мл","package":"120 мл, 50 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