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Его не следует принимать перед госпитализацией и в первые дни госпитализации."}},{"type":"paragraph","data":{"text":"При приступе стенокардии патология коронарных сосудов должна быть заново оценена, и применяемое лечение скорректировано (медикаментозное лечение и. возможно, реваскуляризация)."}},{"type":"paragraph","data":{"text":"Препарат Триметазидин-Тева может вызывать симптомы паркинсонизма (тремор, акинезия, повышение мышечного тонуса) или ухудшать их течение. Следует регулярно контролировать состояние пациентов, особенно в пожилом возрасте. В сомнительных случаях пациента необходимо направить к неврологу для соответствующего обследования."}},{"type":"paragraph","data":{"text":"Развитие двигательных нарушений, таких как симптомы паркинсонизма, синдром беспокойных ног, тремор, шаткость при ходьбе, может привести к отмене триметазидина."}},{"type":"paragraph","data":{"text":"Частота развития двигательных нарушений низкая. Обычно носит обратимый характер, разрешается при прекращении приема препарата. В большинстве случаев после прекращения приема триметазидина пациенты в течение 4 месяцев выздоравливали. Если симптомы паркинсонизма сохраняются более 4 месяцев после отмены препарата, необходима консультация невролога."}},{"type":"paragraph","data":{"text":"При неустойчивой ходьбе или низком мышечном тонусе, особенно при применении антигипертензивной терапии, пациент может упасть."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Данные о применении триметазидина у беременных отсутствуют. Недостаточно данных о применении у животных. Потенциальный риск применения у беременных женщинн еизвестен. Препарат Триметазидин MB-Тева не следует применять во время беременности, если нет очевидной необходимости."}},{"type":"paragraph","data":{"text":"Неизвестно, выделяется ли тримстазидин с грудным молоком, поэтому при необходимости применения препарата Триметазидин MB-Тева в период лактации следует прекратить грудное вскармливание."}},{"type":"paragraph","data":{"text":"В экспериментальных исследованиях не установлено тератогенное действие триметазидина."}},{"type":"paragraph","data":{"text":"Противопоказан в детском и подростковом возрасте до 14 лет."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Принимают внутрь в дозе 40-60 мг/сут, кратность приема 2-3 раза/сут. Продолжительность терапии устанавливают индивидуально, в зависимости от клинической ситуации."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Для оценки частоты развития побочных эффектов использованы следующие критерии: очень часто (≥1/10); часто (≥1/100, <1/10); нечасто (≥1/1000, <1/100): редко (≥1/10000, <1/1000); очень редко (< 1/10000), неизвестная частота - на основании имеющихся данных нет возможности оценить частоту."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: часто - головокружение, головная боль: неизвестная частота - симптомы паркинсонизма (тремор, акинезия, повышенный мышечный тонус), нестабильность походки, синдром \"беспокойных ног\", другие симптомы, относящиеся к двигательным нарушениям, обычно обратимые после прекращения лечения, расстройство сна (бессонница, сонливость)."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: редко - трепетание, экстрасистолия, тахикардия, артериальная гипотензия, ортостатическая гипотензия, которая может быть ассоциирована с недомоганием, головокружением или падением, особенно у пациентов, получающих анти гипертензивное лечение, \"приливы\" крови к лицу."}},{"type":"paragraph","data":{"text":"Со стороны ЖКТ: часто - боль в животе, диарея, диспепсия, тошнота, рвота; неизвестная частота - запор."}},{"type":"paragraph","data":{"text":"Со стороны печени и желчевыводящих путей: неизвестная частота - гепатит."}},{"type":"paragraph","data":{"text":"Со стороны кожных покровов и подкожно-жировой клетчатки: часто - кожная сыпь, зуд, крапивница; неизвестная частота - острое генерализованное экзантемное пустулезное высыпание (AGEP), ангионевротический отек."}},{"type":"paragraph","data":{"text":"Со стороны кроен и лимфатической системы: неизвестная частота - агранулоцитоз, тромбоцитопения, тромбоцитопеническая пурпура."}},{"type":"paragraph","data":{"text":"Прочие: часто - астения."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Имеется ограниченная информация о передозировке триметазидина. В случае передозировки следует проводить симптоматическую терапию."}}]},{"id":6,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"В клинических исследованиях триметазидин не продемонстрировал гемодинамических эффектов, однако в постмаркетинговом опыте применения сообщалось о случаях головокружения и сонливости, которые могут повлиять на способность к управлению транспортными средствами и механизмами."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Триметазидин не влияет на способность к вождению автомобиля и выполнению работ, требующих высокой скорости психомоторных реакций"}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eТаблетки, покрытые пленочной оболочкой, 20 мг.\u003c/i\u003e По 10 табл. в блистере из ПВХ/алюминиевой фольги. По 3 или 6 бл. помещают в картонную пачку, на которую дополнительно могут быть нанесены защитные наклейки.  "}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °C."}},{"type":"paragraph","data":{"text":"\u003ci\u003eХранить в недоступном для детей месте.\u003c/i\u003e"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности, указанного на упаковке"}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Teva (Израиль); производитель"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Меркле ГмбХ, Людвиг-Меркле-Штрассе, 3, 89143, Блаубойрен, Германия."}},{"type":"paragraph","data":{"text":"Наименование держателя (владельца) регистрационного удостоверения лекарственного препарата: Тева Фармацевтические Предприятия Лтд., Израиль."}},{"type":"paragraph","data":{"text":"Организация, принимающая претензии потребителей: ООО «Тева». 115054, Москва, ул. Валовая, 35."}},{"type":"paragraph","data":{"text":"Тел.: (495) 644-22-34; факс: (495) 644-22-35."}}]}],"source":null},"description_toggle":false,"short_description":"Фармакологическое действие - антиангинальное, антигипоксическое, цитопротективное, метаболическое. Непосредственно влияет на кардиомиоциты и нейроны головного мозга, оптимизируя их метаболизм и функции. Цитопротекция обусловлена обеспечением достаточного энергетического потенциала, активацией окислительного декарбоксилирования и рационализацией потребления кислорода (усиление аэробного гликолиза и блокада окисления жирных кислот). Поддерживает сократимость миокарда, предотвращает внутриклеточное истощение АТФ и фосфокреатинина. В условиях ацидоза нормализует функционирование ионных каналов мембран, препятствует накоплению кальция и натрия в кардиомиоцитах, нормализует внутриклеточное содержание калия. Уменьшает внутриклеточный ацидоз и содержание фосфатов, обусловленные ишемией миокарда и реперфузией. 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Почти половина введенного количества подвергается биотрансформации. 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