Врожденные иммунодефицитные состояния (врожденный полный или частичный иммунодефицит, вариационный иммунодефицит, тяжелые комбинированные иммунодефициты, синдром Вискотта-Олдрича); идиопатическая тромбоцитопеническая пурпура (особенно острые формы у детей). Приобретенный иммунодефицит (хроническая лимфоцитарная лейкемия, СПИД у детей, трансплантация ...
Протеин плазмы 50 мг, в т.ч. IgA не более 2 мг, Ig G не менее 96%
Описание
Отпуск иммунобиологического лекарственного препарата ОСУЩЕСТВЛЯЕТСЯ ПО РЕЦЕПТУ ВРАЧА и ПРИ НАЛИЧИИ У ПОКУПАТЕЛЯ ТЕРМОКОНТЕЙНЕРА, в который помещается лекарственный препарат, доставка данного лекарственного препарата в медицинскую организацию при условии хранения в специальном термоконтейнере не должна превышать срок 48 часов после его приобретения.
Фармакологические свойства
Человеческий Ig, восполняя дефицит антител, снижает риск развития инфекций у больных с первичным и вторичным иммунодефицитом.
Показания к применению
Врожденные иммунодефицитные состояния (врожденный полный или частичный иммунодефицит, вариационный иммунодефицит, тяжелые комбинированные иммунодефициты, синдром Вискотта-Олдрича); идиопатическая тромбоцитопеническая пурпура (особенно острые формы у детей). Приобретенный иммунодефицит (хроническая лимфоцитарная лейкемия, СПИД у детей, трансплантация костного мозга и др. виды трансплантаций); синдром Кавасаки (в качестве дополнения к терапии ацетилсалициловой кислотой); профилактика и терапия инфекционных заболеваний.
Противопоказания
Гиперчувствительность, дефицит IgA на фоне наличия у больного антител против IgA. С осторожностью: беременность, период лактации.
Применение при беременности и в период грудного вскармливания
С осторожностью: беременность, период лактации.
Способ применения и дозы
В/в капельно. Перед введением препарат следует согреть до комнатной температуры или температуры тела. Вводить можно только прозрачный раствор. Начальная скорость инфузии - 30 кап/мин (1.65 мл/мин), через 10 мин скорость увеличивают до 40 кап/мин (2.2 мл/мин). Заместительная терапия при первичных и вторичных иммунодефицитах (включая детей со СПИД): 0.1-0.4 г/кг с интервалом в 1 мес до повышения уровня IgG. При отсутствии достаточного повышения уровня IgG или чрезмерно быстром снижении показателя дозу увеличивают до 0.8 г/кг или сокращают интервалы времени между введениями. Идиопатическая тромбоцитопеническая пурпура - 0.8-1 г/кг (при необходимости введение повторяют на 2 или 3 день) или по 0.4 г/кг в течение 2-5 дней. При необходимости курс повторяют. Аллогенная трансплантация костного мозга - 0.5 г/кг в течение 7 дней. Синдром Кавасаки - 1.6-2 г/кг в несколько приемов (в течение 2-5 дней) или 2 г/кг в разовой дозе. При тяжелых бактериальных инфекциях (включая сепсис) и вирусных инфекциях - 0.4-1 г/кг ежедневно в течение 1-4 дней. Для профилактики инфекций у недоношенных детей с низкой массой тела при рождении - 0.5-1 г/кг с интервалом 1-2 нед. При синдроме Гийена-Барре, хронической воспалительной демиелинизирующей невропатии - 0.4 г/кг в течение 5 дней. При необходимости курс лечения повторяют с интервалами 4 нед. У пациентов с ИБС и церебральной ишемией ежедневно вводят 0.4 г/кг.
Побочное действие
Головная боль, озноб, повышение температуры тела, тошнота, рвота, ломота в суставах, боль в спине, аллергические реакции. Редко - снижение АД, в единичных случаях - анафилактический шок, симптомы асептического менингита (сильная головная боль, тошнота, рвота, повышение температуры тела, ригидность затылочных мышц, светочувствительность, нарушение сознания), усугубление почечной недостаточности у пациентов с нарушенной функцией почек.
Передозировка
Передозировка препарата у пациентов, принадлежащих к группе риска, особенно людей престарелого возраста, а также пациентов с нарушением функции почек, может привести к гиперволемии и повышению вязкости крови.
Особые указания
Временное повышение содержания введенных антител в крови пациента после введения Ig может обусловливать ложноположительные результаты серологических проб. Не следует превышать рекомендуемую скорость введения препарата (вероятно развитие тяжелых побочных явлений). В течение всего периода инфузии и 20 мин после нее пациент должен находиться под врачебным контролем.
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