Синтетический прогестин, по химической структуре близок к левоноргестрелу. Обладает прогестагенной активностью. Вызывает переход эпителия эндометрия из пролиферативной фазы в секреторную. Уменьшает вязкость цервикальной слизи. Ингибирует секрецию ЛГ гипофизом и, таким образом, вызывает торможение овуляции. Обладает слабой андрогенной активностью, которая может не проявляться.
Показания к применению
Пероральная контрацепция (в составе комбинированных препаратов).
Применение при беременности и в период грудного вскармливания
Прогестины, обладающие андрогенной активностью, противопоказаны при беременности.
Способ применения и дозы
Средняя суточная доза 150 мкг.
Побочное действие
Возможно: изменение либидо, головная боль, тошнота, рвота, болезненность молочных желез, увеличение массы тела, повышенная склонность к тромбообразованию и увеличение риска развития тромбоэмболии.
Особые указания
Дезогестрел можно применять в сочетании с этинилэстрадиолом.
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